This comprehensive resource, based on evidence and leading practice, helps patients and families, patient advisors, providers, and leaders work together more effectively to improve patient safety. It highlights the value patients offer in preventing patient safety incidents, responding when something goes wrong, and learning to build safer care. It provides comprehensive understanding of why and how to engage with patients and families for safer, quality care at the direct level of care, and at organization and system levels, and considerations of how to evaluate both processes and outcomes of engagement at these levels. To complement the guide, a collection of tools and resources are available throughout it.